The first post dealt with rising skin
cancer rates in N. America. Up to 4 million Americans and 120,000 Canadians
will develop a skin cancer this year. One in six Canadians and one in five
Americans will develop a skin cancer within their lifetime. More alarming, is
the rising rate for all skin cancer but particularly the rate for melanoma. The last post dealt with the public health and
economic dimensions of the problem. Scarce
health care resources are spent on a preventable disease and costs continue to
rise. In Canada up to 1/4 million cases of skin cancer could cost over one billion
by 2030. Collectively, we need a new strategy. There is a need for new public
health policy, but after years of trying to engage public officials, I have
come to the conclusion that they are either unable or unwilling to frame effective
solutions. Each of us must adopt our own public health measures and educate or encourage
our entire circle of friends, relatives and contacts.
The Basics:
Figure 1: The Iconic Coppertone Baby |
Everyone can adopt a simple approach to sun
safety motivated by wanting to lower your risk for skin cancer, to reduce
photoaging and retain a younger appearance, or simply do it for public
responsibility. First, an understanding of basic photobiology. Sunlight
contains visible light at 400-760 nm and
ultraviolet (UV) at
wavelengths 290-400 nm. Longer infra-red beyond 760 nm gives you the feeling of
warmth on your skin and also has negative effects. However, most sun-damage
comes from UV that accounts for 5% of total
sunlight. Sunscreens are supposed to absorb, scatter, or reflect
this entire range of invisible UV energy - UVB (290-320nm) and UVA (320-400nm),
which is split into shortwave UVA (UVA-II at 320-340nm) and longwave UVA (UVA-I
at 340-400nm). Most Canadians will be
using sunscreens that filter UVB and provide inadequate or no protection to
harmful UVA radiation, particularly in the UVA-I band. UVA
accounts for 95% of the UV radiation reaching a person and is 15
times more potent on earth than UVB. It is illogical for sunscreens to be
UVB-biased, as they are in N.America, providing most protection against UVB.
Sunscreens need to provide balanced protection aiming for equal attenuation at every
wavelength. The word ‘balanced’ will be a recurring refrain in this series.
Your ability to identify and use a sunscreen with balanced UV protection will
be the ultimate part of a smart sun protection hierarchy. The iconic Coppertone
ad (Figure1) shows the graphic profile of the UVB sunscreen that allowed
tanning without burning – UVB biased. Newer sunscreens give some more UVA-II
protection but the ideal and safest sunscreen would be balanced, depicted by
the profile at the right- similar to the lady shaded by a parasol. This is
defined as balanced protection or spectral homeostasis – where a sunscreen
affords virtually equal protection at every wavelength across the entire UV
spectrum from 290-400 nm.
What to do?
Figure 2: The Fitzpatrick Skin Type Classification |
Figure 3: Time To Burn Based on Skin Type |
The next
step is to be aware of the harmful effects of UV radiation. All types of skin
cancer can occur in areas never exposed to the sun, but the majority are
related to effects of UV radiation. It is estimated sun damage causes 90% of
non melanoma skin cancer and 65% of melanomas, and most are potentially preventable.
Sunburn and the erythema effect (the visible warning sign of UV skin damage) is
caused almost entirely by UVB and UVA-I (290-340nm). Figure 2 gives the
classification dermatologists use and Figure 3 shows the time for unprotected
skin to burn. Unprotected white skin (Type I) can show mild erythema and
sunburn after 1-2 minutes under the tropical summer sun at noon. UVA radiation may be more harmful than UVB
with a wider scope of skin damage- immune suppression, accelerated photoaging,
and skin cancer. UVA as a longer wavelength penetrates deeper than UVB. 20 times more UVA, particularly the deeper
penetrating UVA-I, reaches fragile proliferating cells in the basal layer of
the epidermis and harmful effects even extend below the dermis (Figure 4). UVB
triggers the sunburn and tanning response. UVA that penetrates deeper and
stimulates the melanin response in the dermis responsible for the deeper and
longer lasting tan. That is why the early sunscreens were formulated to prevent
sunburn but to allow tanning by being UVB-biased. They blocked UVB and
inhibited sunburn but allowed harmful UVA rays to stimulate a tan in melanin-competent
skin- usually Skin Types III-V. Do not consider a tan as UV protection. It is
a protective response that says damage to your skin has occurred. The role of
harmful UVA rays in tanning is also the reason why dangerous tanning beds use
pure UVA light. This ill-advised way to tan is linked to the dramatic rise in
melanoma rates in younger patients, particularly females under 30.
Figure 4: Detrimental Effects of UV to Human Skin |
The
hierarchy of Sun Smart or Sun Safety Campaigns begins with being aware of the
UV-Index and linking your dress and sun-avoidance behaviour accordingly. See
Figure 5&6, for what the index means and sensible measures you should adopt.
We recommend a daily balanced sunscreen every day to exposed skin. The UVA band
is ubiquitous- almost constant with time of day or at any latitude- 70-80% penetrates
clouds or fog, and window or auto glass. UV radiation dose increases by 5% for
every 1000’ rise in altitude. Winter can
actually be worse as snow can increase your exposure by 80% due to reflection
by snow – as does sand and concrete. The UV Index is global but my informal
study suggests that < 30% of Canadians know what it means and actively look
for it every day. In contrast, 96% of Danes know what the UV-Index is and 89%
know how to interpret it. Up to 50%% key the index to behaviour and decisions
about sun-protection, particularly for children living at home. Our only added
precaution is that even when the index is low, you should use a balanced sunscreen
everyday to prevent UVA exposure that is difficult to limit any other way.
A UVA burn is deep and painful as many who go sailing or recreate on cloudy
days can confirm. It is harder to reduce your UVA exposure by just staying out
of the sun. The best way is to add every morning use of a balanced sunscreen to
sun avoidance measures (there is that word- balanced again). This will reduce
your risk of skin cancer and retard photoaging by up to 25 years. Used from the
teenage years this can mean that when you are 70 it is possible to look like
you are 45. We recommend use of a daily balanced sunscreen with filters that do
not enter the body, in every person over 6 months of age.
Figure 5: Deciphering the UV Index System |
We can now make balanced sunscreens that
give as much UVA protection as UVB. I am presently working with scientists in
Europe to make such a sunscreen that will mimic the protective effects of shade
or black clothing. The benefits are exciting compared to the limitations and
dangers of unbalanced UVB-biased sunscreens, with minimal UVA protection that
now dominate the market in N. America. A few UV filters are able to achieve a
balanced UVB to UVA protection approaching unity. These include zinc oxide,
Tinosorb S™ and Tinosorb M™, and Mexoryl XL™, in tailored combinations.
Interestingly, these filters also belong to a group of 7 filters with large
molecules that do not enter the skin. This gives them the best safety profiles
favored by consumer groups. Look for these agents in combination with each
other or titanium dioxide, and no other active ingredients. Many products that use these agents add the other
organic filters with small molecular weights that quickly penetrate your skin into
blood and all your tissues. There are several potential dangers – links to
cancers and hormone disruption and photoallergy. A prudent approach would be to
avoid these risks and use filters that do not enter the body.
Figure 6: How Best To Protect Yourself |
Zinc oxide is the only single agent used in concentrations of 15% and over that gives adequate
SPF values, and relatively balanced protection. New formulas can be very aesthetic and go on clear. Look for EWG preferred sunscreens such as our Simply Zinc Sun Whip, if you can pardon the plug but these are the concepts we used to formulate it.
The next post will deal
with details of UV effects and the benefits of reducing your lifetime exposure.
Later posts will show the differences in UVA protection between a balanced and
a UVB biased sunscreen, and assist the reader in selecting a balanced product
from among the minority of those
available in N. America.